In Florida, Trish Jenner (Gina Philips) and her brother Darry (Justin Long) are traveling home from college for spring break. On the road, they spot the driver of an old truck dumping several bodies into a large pipe outside an abandoned church. Deciding to investigate, Darry finds a lair containing hundreds of dead bodies. At a diner, the pair receive a call from Jezelle Gay Hartman (Patricia Belcher), a woman who tells them that they are going to be tracked down by the driver, revealed to be an ancient demonic creature known as the Creeper (Jonathan Breck) who kills and eats people every twenty-three years for twenty-three days. Searching for help at a police station, the brother-and-sister duo meets Jezelle, who warns them again before the Creeper arrives. After a chase, the Creeper captures Darry and flies away with him, leaving Trish depressed and in shock.

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